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Published on: February 15, 2022
Eye cancer related glaucoma: current concepts
Nathan M Radcliffe1, Paul T Finger
1The New York Eye Cancer Center, New York University School of Medicine, New York City, NY, USA.
Abstract:
Eye cancer-related glaucomas occur through a variety of mechanisms. They can be challenging to diagnose and are often refractory to treatment. The literature reveals the variety of ways eye cancers cause glaucoma. Mechanisms include direct invasion, infiltration, or seeding of the aqueous outflow structures as well as indirect processes, such as compressive angle closure and anterior segment neovascularization. This review describes established, evolving, and new diagnostic techniques (e.g., high-frequency ultrasound and aspiration biopsy techniques). Treatment options typically depend upon the tumor type (primary or secondary), its location, and mechanism of glaucoma. However, they include standard pharmacologic, laser, incisional, and radiotherapeutic approaches. We hope this review leads to early detection and optimum treatment of eye cancer-related glaucomas. Clearly, prompt diagnosis and management of eye cancer-related glaucoma offers an opportunity to both preserve vision and the patient's life.
Insights
Eye cancers can cause glaucoma through various mechanisms, making diagnosis and treatment difficult. Early detection and management of these eye cancer-related glaucomas are crucial for preserving vision and life.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Eye cancer can lead to glaucoma via direct invasion or indirect mechanisms like angle closure.
- These conditions are often difficult to diagnose and treat effectively.
Purpose of the Study:
- To review the diverse mechanisms by which eye cancers induce glaucoma.
- To discuss established and novel diagnostic and therapeutic strategies for eye cancer-related glaucoma.
Main Methods:
- Literature review of established, evolving, and new diagnostic techniques.
- Discussion of treatment options based on tumor type, location, and glaucoma mechanism.
Main Results:
- Eye cancers cause glaucoma through direct invasion/infiltration of outflow structures or indirect processes.
- Diagnostic tools include high-frequency ultrasound and aspiration biopsy.
- Treatment encompasses pharmacologic, laser, incisional, and radiotherapeutic approaches.
Conclusions:
- Prompt diagnosis and management of eye cancer-related glaucoma are vital.
- Effective treatment can preserve both vision and patient life.
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