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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Related Experiment Video

Updated: Jun 26, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

Human papillomaviruses: a growing field.

Denise A Galloway¹

¹Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. dgallowa@fhcrc.org

Genes & Development

|January 28, 2009

Summary

Researchers developed a new method to grow infectious human papillomavirus (HPV) in differentiating epithelial cells. This breakthrough provides evidence for the temporal separation of viral and cellular replication, advancing our understanding of HPV life cycles.

Area of Science:

Virology
Molecular Biology
Cell Biology

Background:

Human papillomavirus (HPV) is causally linked to cervical cancer etiology.
Understanding the HPV viral life cycle has been challenging.
Previous research relied on functional and epidemiological studies.

Discussion:

Wang et al. present an efficient method for propagating infectious HPV in differentiating epithelium.
This technique allows for detailed study of the HPV life cycle in a relevant cellular context.
The findings provide clear evidence for the temporal separation of viral and cellular replication.

Key Insights:

Successful propagation of infectious HPV in vitro.
Demonstration of distinct temporal phases for viral and cellular replication.

More Related Videos

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

Related Experiment Videos

Last Updated: Jun 26, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

A new tool for investigating HPV pathogenesis and replication strategies.

Outlook:

This method will facilitate further research into HPV replication mechanisms.
Potential for developing novel antiviral strategies targeting HPV.
Enhanced understanding of HPV's role in cancer development.