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Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

Overview
Pedigree Analysis01:35

Pedigree Analysis

Overview
Trihybrid Crosses02:27

Trihybrid Crosses

Trihybrid Crosses
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal chance to...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Karyotyping01:17

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
Law of Segregation01:49

Law of Segregation

When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.

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Updated: Jun 26, 2026

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
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Haplotyping methods for pedigrees.

Guimin Gao1, David B Allison, Ina Hoeschele

  • 1Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Ala., USA.

Human Heredity
|January 28, 2009
PubMed
Summary
This summary is machine-generated.

This review surveys haplotyping methods for family and pedigree data, crucial for understanding genetic diseases and traits. It details available tools and discusses their applications, limitations, and future challenges in genetic studies.

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Area of Science:

  • Genetics
  • Bioinformatics
  • Computational Biology

Background:

  • Haplotypes are essential for studying diseases, complex traits, population history, and evolutionary genetics.
  • The increasing number of single nucleotide polymorphism (SNP) markers makes haplotype inference (haplotyping) vital for genetic studies and statistical gene mapping.
  • Existing haplotyping methods are categorized into population-based, pooled DNA, and family/pedigree data approaches.

Purpose of the Study:

  • To review haplotyping methods and computer programs specifically designed for family and pedigree data.
  • To discuss the applications and limitations of these family-based haplotyping methods.
  • To explore the interconnections between different haplotyping methodologies and identify remaining challenges.

Main Methods:

  • Literature review of existing haplotyping methods for family and pedigree data.
  • Analysis of associated computer programs, their functionalities, and suitability for genetic research.
  • Comparative discussion of the strengths and weaknesses of various family-based haplotyping techniques.

Main Results:

  • Identified and categorized numerous haplotyping methods and software for family/pedigree datasets.
  • Evaluated the practical applications and inherent limitations of these tools in genetic analysis.
  • Highlighted the advantages of family and pedigree datasets for accurate haplotype inference.

Conclusions:

  • Family and pedigree data offer unique advantages for haplotype inference, crucial for genetic research.
  • A comprehensive understanding of available methods and tools is necessary for effective application.
  • Further research is needed to address existing challenges and advance haplotyping methodologies.