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Updated: Jun 26, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Temsirolimus in patients with advanced renal cell carcinoma: an overview

Shailender Bhatia1, John A Thompson

  • 1Division of Medical Oncology, Department of Medicine, University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. sbhatia@u.washington.edu

Advances in Therapy
|January 28, 2009
PubMed

Insights

Temsirolimus, a mammalian target of rapamycin (mTOR) inhibitor, offers significant benefits for advanced renal cell carcinoma (RCC) patients with poor prognosis. This review details its role in the evolving landscape of RCC treatment.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Advanced renal cell carcinoma (RCC) treatment has been revolutionized by targeted therapies.
  • Temsirolimus, an inhibitor of mammalian target of rapamycin (mTOR), shows efficacy in advanced RCC with poor prognosis.

Purpose of the Study:

  • To review the rationale for using mTOR inhibitors in RCC treatment.
  • To discuss the pharmacokinetics, toxicities, and clinical trials of temsirolimus in advanced RCC.
  • To outline the indications and current status of temsirolimus in the evolving therapeutic landscape of advanced RCC.

Main Methods:

  • Literature review of clinical trials and pharmacological data.
  • Analysis of temsirolimus's efficacy and safety profile in advanced RCC.
  • Discussion of the current treatment guidelines and future directions.

Main Results:

  • Temsirolimus has demonstrated clinical benefit in patients with advanced RCC and poor prognostic factors.
  • Understanding the pharmacokinetics and toxicities is crucial for effective temsirolimus use.
  • Landmark trials support the use of temsirolimus in specific RCC patient populations.

Conclusions:

  • Temsirolimus is a valuable therapeutic option for advanced RCC, particularly in poor-prognosis cases.
  • Its role is considered within the context of a rapidly changing treatment environment.
  • Further research may refine temsirolimus's application in combination therapies.

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