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Neurocognitive functioning of a child with partial trisomy 6 and monosomy 21

Jennifer M Katzenstein1, John S Oghalai, Ross Tonini

  • 1Indiana University-Purdue University, Indianapolis, IN, USA.

Neurocase
|January 28, 2009
PubMed

Insights

This case study examines a child with trisomy 6 and monosomy 21 genetic abnormalities and profound hearing loss. Cochlear implantation showed some skill improvement, though oral language development remains limited.

Area of Science:

  • Genetics
  • Neuroscience
  • Audiology

Background:

  • A child with trisomy 6 and monosomy 21 genetic abnormalities was evaluated for profound sensorineural hearing loss.
  • The evaluation was part of the standard medical protocol for cochlear implantation.

Observation:

  • Neurocognitive testing was performed before cochlear implantation and 12 months after activation.
  • The child presented with limited oral language development.

Findings:

  • Post-cochlear implant activation, the child demonstrated improvement in overall neurocognitive skills.
  • The observed skill improvement was less than what is typically expected for a developing child.

Implications:

  • Cochlear implantation may offer benefits for neurocognitive development in children with complex genetic abnormalities and hearing loss.
  • Further research is needed to understand the long-term neurocognitive outcomes and optimize interventions for this population.

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