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Related Experiment Videos

Circulating serum trefoil factors increase dramatically during pregnancy.

M Hessellund Samson¹, E M Vestergaard, N Milman

¹Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark. mhsam@as.aaa.dk

Scandinavian Journal of Clinical and Laboratory Investigation

|January 28, 2009

Summary

Circulating trefoil factors (TFF1-3) are not reliable markers for trisomy 21 during pregnancy. Levels of TFFs change significantly during gestation and postpartum, but do not differ between pregnancies with trisomy 21 and normal pregnancies.

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Area of Science:

Biochemistry
Genetics
Maternal-Fetal Medicine

Background:

Trefoil factors (TFF1-3) are peptides secreted by mucosal surfaces, with gene locations on chromosome 21.
Altered TFF levels are sometimes associated with genetic conditions like trisomy 21.

Purpose of the Study:

To investigate circulating trefoil factor (TFF) levels in pregnant women carrying trisomy 21 fetuses compared to normal pregnancies.
To analyze TFF levels throughout pregnancy and postpartum.

Main Methods:

Serum samples were collected from pregnant women at various gestational weeks (GW) and postpartum.
Enzyme-linked immunosorbent assay (ELISA) was used to quantify TFF1, TFF2, and TFF3 concentrations.
Study included women with normal pregnancies (n=141) and those carrying trisomy 21 fetuses (n=48).

Main Results:

TFF2 and TFF3 levels peaked at 39 GW, significantly higher than postpartum levels.
TFF1 concentrations increased throughout pregnancy and postpartum.
No significant differences in TFF levels were observed between women carrying trisomy 21 fetuses and those with healthy fetuses.

Conclusions:

Circulating trefoil factors (TFFs) are not suitable as first-trimester markers for trisomy 21.
The study highlights novel findings regarding TFF production during pregnancy and prompts further investigation into their physiological roles.