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Decision making during the conception and career of CD4+ T cells
Nature Reviews. Immunology
|January 28, 2009
Abstract:
The mechanisms by which thymocytes commit to becoming CD4+ T cells and how these cells subsequently can adopt various cell fates are becoming important paradigms of developmental programming. Understanding how such CD4+ T-cell diversity accommodates both immune reaction against various challenges and the suppression of undesirable responses is also revealing new therapeutic options.
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