Related Experiment Videos
Guanidination of a peptide side chain amino group on a solid support
1Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis.
International Journal of Peptide and Protein Research
|May 1, 1991
Abstract:
A novel guanidination method of converting a peptide side chain amino group to a guanidino group on a solid support is described. Four guanidinating reagents were evaluated using a model tetrapeptide attached to a polystyrene resin. Experimental data indicate that the two nitroguanidinating reagents, but not the two tosylguanidinating reagents, can be used effectively in solid phase peptide synthesis.