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Phacoanaphylactic endophthalmitis: a clinicopathologic review
A B Thach1, G E Marak, I W McLean
1Walter Reed Army Medical Center, Washington, D.C. 20307.
International Ophthalmology
|July 11, 1991
Summary
Phacoanaphylactic endophthalmitis (PE), an eye inflammation after lens rupture, is often misdiagnosed. This chronic condition frequently follows trauma and can affect deeper eye structures.
Area of Science:
- Ophthalmology
- Pathology
Background:
- Lens-induced uveitis, or phacoanaphylactic endophthalmitis (PE), is a chronic inflammatory eye condition.
- It is characterized by granulomatous inflammation surrounding a ruptured lens.
Purpose of the Study:
- To retrospectively evaluate the clinical and histopathological features of 144 cases of phacoanaphylactic endophthalmitis.
- To assess the clinical recognition and pathological extent of PE.
Main Methods:
- Retrospective analysis of 144 clinical and histopathological cases of PE.
- Review of patient history, including trauma, surgical history, and age.
Main Results:
- Only 6% of PE cases received a clinical diagnosis, indicating poor clinical recognition.
- 80% of cases occurred post-trauma (surgical or non-surgical), with a wide time range after injury.
- Inflammation extended to the choroid in 76% of cases, challenging the classical anterior-confined description.
Conclusions:
- Phacoanaphylactic endophthalmitis is frequently underdiagnosed clinically.
- Trauma is a major cause, and the inflammation can be extensive, involving posterior structures of the eye.