A temperature-sensitive liposomal 1H CEST and 19F contrast agent for MR image-guided drug delivery
Sander Langereis1, Jochen Keupp, Juliën L J van Velthoven
1Philips Research Europe, High Tech Campus 11, 5656 AE Eindhoven, The Netherlands. sander.langereis@philips.com
Journal of the American Chemical Society
|January 29, 2009
Abstract:
A novel temperature-sensitive liposomal MRI contrast agent has been developed, which allows drug carrier localization using (1)H CEST with simultaneous quantification of the drug release using (19)F MR imaging in response to a local temperature increase.


