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Updated: Jun 26, 2026
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
[Thyroid disorders and childhood rheumatic diseases]
C Alvarez Madrid1, A González Fernández, M Lisbona Muñoz
1Sección de Reumatología Pediátrica, Hospital Universitario La Paz, Madrid, España.
Anales De Pediatria (Barcelona, Spain : 2003)
|January 29, 2009
Summary
Thyroid abnormalities affect over 4% of children with rheumatic diseases, particularly those with juvenile idiopathic arthritis and lupus. Early thyroid hormone screening is recommended for these pediatric patients.
Area of Science:
- Pediatric Rheumatology
- Endocrinology
- Autoimmune Diseases
Context:
- The link between thyroid dysfunction and autoimmune conditions is established in adults.
- Limited data exists on thyroid abnormalities in pediatric rheumatic diseases.
Purpose:
- To determine the prevalence and characteristics of thyroid abnormalities in children diagnosed with rheumatic diseases.
- To investigate the association between thyroid dysfunction and specific pediatric rheumatic conditions.
Summary:
- A two-year study of 145 pediatric rheumatology patients revealed thyroid abnormalities in 4.14% of cases.
- Juvenile idiopathic arthritis (JIA) and lupus were the most common diagnoses among affected children.
- All patients with thyroid dysfunction tested positive for antinuclear antibodies (ANA), suggesting a strong autoimmune link.
Impact:
- Highlights the significant prevalence of thyroid dysfunction in pediatric rheumatic diseases.
- Suggests routine thyroid hormone monitoring for children with JIA and lupus.
- Emphasizes the importance of early detection and management of thyroid disorders in this vulnerable population.
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