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Is peritoneal dialysis a suitable renal replacement therapy in autosomal dominant polycystic kidney disease?

Eric Goffin1, Yves Pirson

  • 1Division of Nephrology at Cliniques Universitaires St Luc, Université Catholique de Louvain, Brussels, Belgium.

Nature Clinical Practice. Nephrology
|January 29, 2009
PubMed

Insights

Peritoneal dialysis is a viable option for autosomal dominant polycystic kidney disease (ADPKD) patients, showing similar survival and peritonitis rates compared to non-diabetic controls. Further research should explore its suitability in patients with significantly enlarged kidneys or liver.

Area of Science:

  • Nephrology
  • Renal Replacement Therapy

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) management often involves renal replacement therapy.
  • Peritoneal dialysis (PD) outcomes in ADPKD patients require further investigation.

Discussion:

  • A study compared PD outcomes in 56 ADPKD patients with a matched control group.
  • Key metrics included patient survival, technique survival, and peritonitis rates over a mean of 37 months.
  • The study found comparable outcomes between ADPKD patients on PD and the control group.

Key Insights:

  • Peritoneal dialysis was feasible and successful in 68% of ADPKD patients studied.
  • No significant differences in patient survival, technique survival, or peritonitis rates were observed.
  • The study suggests PD is a potentially effective treatment modality for ADPKD.

Outlook:

  • The study did not compare PD with hemodialysis (HD) for ADPKD patients, particularly those with very large cystic kidneys or livers.
  • Future research should investigate renal replacement modalities in ADPKD, correlating outcomes with kidney and liver volumes.
  • Comparative studies are needed to determine the optimal renal replacement therapy for ADPKD patients with significant organ enlargement.

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