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A case of tuberous sclerosis complex that progressed to end-stage renal disease

Mohammad Sarraf¹, Amirali Masoumi, Fernando J Castro-Silva

¹Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80220, USA. mohammad.sarraf@uchsc.edu

Nature Clinical Practice. Nephrology

|January 29, 2009

Abstract

Background:

A 31-year-old woman with tuberous sclerosis complex presented with a 1 week history of subjective fever, chills, rigors, poor appetite and dizziness.

Investigations:

Physical examination, urine and blood analysis, CT of the abdomen, chest and brain, and chest X-ray.

Diagnosis:

End-stage renal disease, septic shock and urinary tract infection secondary to huge bilateral angiomyolipomas of the kidney associated with tuberous sclerosis complex.

Management:

Antibiotic therapy, vasopressor treatment and bilateral nephrectomy, followed by hemodialysis while awaiting renal transplantation.

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