Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Pedigree Analysis01:35

Pedigree Analysis

Overview
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thrombophilic risk of individuals with rare compound factor V Leiden and prothrombin G20210A polymorphisms: an international case series of 100 individuals.

European journal of haematology·2016
Same author

Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls.

European journal of epidemiology·2013
Same author

Widening the mutation spectrum of EVC and EVC2: ectopic expression of Weyer variants in NIH 3T3 fibroblasts disrupts Hedgehog signaling.

Human mutation·2009
Same author

Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure.

Human reproduction (Oxford, England)·2006
Same author

p-p70S6K (Thr 389) Expression in nodular sclerosing hodgkin's disease as evidence for receptor tyrosine kinase signaling.

Annals of clinical and laboratory science·2005
Same author

Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR G677A among 594 thrombotic Jordanian patients.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2005

Related Experiment Videos

Inherited bleeding disorders: a 14-year retrospective study.

Suhair S Eid1, Nazmi R Kamal, Taisir S Shubeilat

  • 1Coagulation Section-Haematology Department, Princess Iman Research and Laboratory Sciences Center, King Hussein Medical Center, Amman, Jordan. sueeid@gmail.com

Clinical Laboratory Science : Journal of the American Society for Medical Technology
|January 30, 2009
PubMed
Summary

This study investigated bleeding disorders in Jordanian patients, finding factor deficiencies in 41.6%. Hemophilia A, von Willebrand disease, and Hemophilia B were most common, alongside rare inherited coagulation deficiencies.

Related Experiment Videos

Area of Science:

  • Hematology
  • Coagulation Disorders
  • Epidemiology

Background:

  • Congenital bleeding disorders are a diverse group of diseases affecting blood vessels, coagulation proteins, and platelets.
  • Understanding the prevalence and clinical manifestations of these disorders is crucial for patient management.

Purpose of the Study:

  • To assess the prevalence of bleeding disorders among Jordanians.
  • To describe the clinical manifestations of diagnosed bleeding disorders.

Main Methods:

  • A 14-year retrospective study (1991-2005) of patients with bleeding tendencies.
  • Screening with routine coagulation assays and complete blood cell count.
  • Factor assays performed based on screening results.

Main Results:

  • 403 patients met the criteria; 168 (41.6%) had factor deficiency bleeding disorders.
  • Prevalence: Hemophilia A (17.1%), von Willebrand disease (6.2%), Hemophilia B (4.2%).
  • Rare Inherited Coagulation Deficiencies (RICD) affected 14.1%, including Factor X, VII, V, XI deficiencies, and afibrinogenemia.

Conclusions:

  • Factor deficiencies represent a significant portion of bleeding disorders in the Jordanian population.
  • Hemophilia A, vWD, and Hemophilia B are the most prevalent, but RICDs also warrant attention.