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Related Experiment Video

Updated: Jun 26, 2026

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
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Published on: May 9, 2014

Feasibility study for linac-based intensity modulated total marrow irradiation.

Joel R Wilkie1, Hanifi Tiryaki, Brett D Smith

  • 1Center for Molecular Biology of Oral Diseases, University of Illinois Chicago, Chicago, Illinois 60612, USA.

Medical Physics
|January 30, 2009
PubMed
Summary

Intensity modulated total marrow irradiation (IMTMI) shows promise for reducing radiation toxicity in bone marrow transplants. This technique accurately delivers radiation doses, significantly lowering exposure to critical organs compared to conventional total body irradiation (TBI).

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Last Updated: Jun 26, 2026

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

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Published on: May 9, 2014

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Irradiator Commissioning and Dosimetry for Assessment of LQ &alpha; and &beta; Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

  • Radiation Oncology
  • Medical Physics

Background:

  • Total body irradiation (TBI) is a standard preconditioning regimen for bone marrow transplantation in hematologic malignancies.
  • TBI irradiates large normal tissue volumes, leading to significant toxicities, particularly in the lungs.

Purpose of the Study:

  • To assess the feasibility of intensity modulated total marrow irradiation (IMTMI) for reducing normal tissue toxicity.
  • To evaluate the accuracy of dose delivery for IMTMI using a Rando phantom and a three isocenter technique.

Main Methods:

  • A three isocenter technique was employed for full body treatment planning on a linear accelerator.
  • Thermoluminescent detectors (TLDs) and ion chambers were used to verify dose delivery accuracy in phantom studies.
  • Intensity modulated radiation therapy (IMRT) verification plans were delivered to a solid water phantom.

Main Results:

  • IMTMI achieved target coverage while reducing doses to critical structures by 29%-65% compared to conventional TBI.
  • TLD readings showed an average dose delivery difference of 3.5% from the calculated dose.
  • Ion chamber and film measurements confirmed accurate dose delivery and distribution.

Conclusions:

  • IMTMI using a three isocenter technique is feasible and can be accurately delivered.
  • This technique offers substantial dose reductions to critical structures, potentially mitigating TBI-related toxicities.