Related Experiment Videos
Lipophilic 99mTc-nitride radiopharmaceuticals as potential myocardial imaging agents
J R Dilworth1, C M Archer, I A Latham
1Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, Colchester, England.
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|January 1, 1991
Abstract:
Monocationic 99mTc-nitrido complexes of a variety of diphosphine ligands have been prepared and the in vivo distribution of such cations has been examined in Sprague-Dawley rats. These complexes show initially high myocardial uptake with subsequent wash-out in this animal model. The lack of myocardial retention can be attributed to the facile in vivo reduction of these cations.