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Published on: September 20, 2021
Microhandling of vesicular glutamate uptake modulate feeding in broilers
A Baghbanzadeh1, M Modirsaneie, G Emam
1Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. abaghban@ut.ac.ir
Journal of Animal Physiology and Animal Nutrition
|January 30, 2009
Summary
Chicago sky blue 6B (CSB6B), a glutamate uptake inhibitor, increased feed intake and reduced feeding latency in broilers. This study explores CSB6B
Area of Science:
- Neuroscience
- Animal Science
- Physiology
Background:
- Glutamate (Glu) is a key excitatory neurotransmitter in the central nervous system.
- Intracerebroventricular (ICV) glutamate influences feeding behavior in broilers.
- Vesicular glutamate transporter research has primarily focused on mammals.
Purpose of the Study:
- To investigate the effect of Chicago sky blue 6B (CSB6B), a glutamate vesicular uptake inhibitor, on feed intake and feeding latency in broilers.
- To examine the role of vesicular glutamate transport in avian feeding behavior.
Main Methods:
- Four experiments involving ICV injections in Ross 208 broilers.
- Treatments included saline, glutamate (Glu), CSB6B, and a combination of Glu and CSB6B.
- Broilers were subjected to a 24-hour feed deprivation period prior to testing.
Main Results:
- CSB6B significantly increased feed intake in broilers.
- CSB6B administration decreased the latency to start feeding.
- Glutamate administration alone did not show significant effects on feeding behavior.
Conclusions:
- Inhibition of vesicular glutamate uptake by CSB6B stimulates feeding behavior in broilers.
- Vesicular glutamate transport is a viable target for modulating feeding behavior in poultry.
- Further research into avian vesicular glutamate transporters is warranted.
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