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HLA antigens influence resistance to lung carcinoma
P J Romano1, M Bartholomew, P J Smith
1Department of Pharmacology, Pennsylvania State University, College of Medicine, Hershey 17033.
Human Immunology
|August 1, 1991
Abstract:
The concept of genetic factors playing a role in the pathogenesis of lung cancer has gained increased attention. The present study was undertaken to reexamine the question of HLA antigen association with carcinoma of the lung. In a study of 90 patients, a significant association occurred between HLA-DR7 and resistance to lung cancer, after accounting for smoking status and sex. HLA class I antigens were also implicated. These results suggest that major histocompatibility complex loci affect carcinoma of the lung.