Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of the type of volatile anesthetic on the development of acute kidney injury after endovascular repair of aortic aneurysm: a randomized controlled trial (DESEVAR study).

Frontiers in pharmacology·2025
Same author

Usefulness of serum neurofilament light chain in chronic inflammatory demyelinating polyradiculoneuropathy.

Journal of the neurological sciences·2025
Same author

Consensus statement of the Spanish Society of Neurology on the treatment of multiple sclerosis and holistic patient management in 2023.

Neurologia·2024
Same author

Natural language processing tools for non-clinical healthcare management.

Journal of healthcare quality research·2023
Same author

Angiogenic imbalance in maternal and cord blood is associated with neonatal birth weight and head circumference in pregnancies with major fetal congenital heart defect.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023
Same author

Assessing the Equivalence of Brain-Derived Measures from Two 3D T1-Weighted Acquisitions: One Covering the Brain and One Covering the Brain and Spinal Cord.

AJNR. American journal of neuroradiology·2023

Related Experiment Video

Updated: Jun 26, 2026

Measurement of Chitinase Activity in Biological Samples
03:32

Measurement of Chitinase Activity in Biological Samples

Published on: August 22, 2019

Plasma chitotriosidase activity in multiple sclerosis.

M Comabella1, C Domínguez, J Rio

  • 1Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain. mcomabel@ir.vhebron.net

Clinical Immunology (Orlando, Fla.)
|January 30, 2009
PubMed
Summary
This summary is machine-generated.

Plasma chitotriosidase (Chit) activity is elevated in multiple sclerosis (MS) patients. However, this enzyme

More Related Videos

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Related Experiment Videos

Last Updated: Jun 26, 2026

Measurement of Chitinase Activity in Biological Samples
03:32

Measurement of Chitinase Activity in Biological Samples

Published on: August 22, 2019

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Area of Science:

  • Neuroimmunology
  • Enzymology
  • Biochemistry

Background:

  • Chitotriosidase (Chit) is an enzyme implicated in inflammatory processes.
  • Its role in the pathogenesis of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is under investigation.

Purpose of the Study:

  • To investigate plasma chitotriosidase (Chit) activity in multiple sclerosis (MS) patients.
  • To determine if Chit activity correlates with MS clinical course or response to interferon-beta (IFNβ) treatment.

Main Methods:

  • Plasma Chit activity was measured using a fluorometric enzyme activity assay.
  • The study included 219 untreated MS patients and 160 healthy controls (HC).
  • Chit activity was also assessed in 46 MS patients undergoing interferon-beta (IFNβ) therapy.

Main Results:

  • Plasma Chit activity was significantly higher in MS patients compared to healthy controls (HC).
  • No significant differences in Chit activity were found between relapsing-progressive and progressive MS forms.
  • Chit activity remained consistent during relapse and remission phases in MS patients.
  • Interferon-beta (IFNβ) treatment led to a significant increase in Chit activity, irrespective of treatment response.

Conclusions:

  • Elevated plasma chitotriosidase (Chit) suggests a potential role in multiple sclerosis (MS) pathogenesis.
  • Plasma Chit activity does not appear to be associated with the clinical course of MS.
  • Chit activity levels do not predict clinical response to interferon-beta (IFNβ) treatment in MS patients.