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Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

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Copper-associated hepatitis in Labrador Retrievers.

R Smedley¹, T Mullaney, W Rumbeiha

¹Diagnostic Center for Population and Animal Health, 4125 Beaumont Road, Lansing, MI 48910, USA. Smedley@dcpah.msu.edu

Veterinary Pathology

|January 30, 2009

Summary

Primary copper-associated hepatitis is likely occurring in Labrador Retrievers. This study identified characteristic liver lesions and high copper levels in affected dogs, suggesting a breed predisposition.

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Last Updated: Jun 26, 2026

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Area of Science:

Veterinary Pathology
Canine Hepatology

Background:

Elevated hepatic copper levels are known in Labrador Retrievers.
Primary copper-associated hepatitis has not been definitively identified in this breed.

Purpose of the Study:

To determine if copper-associated hepatitis occurs in Labrador Retrievers.
To characterize the pathological findings in affected dogs.

Main Methods:

Retrospective review of cases from a diagnostic laboratory.
Histopathological examination of liver tissues stained with rhodanine.
Quantitative analysis of liver copper levels.

Main Results:

Sixteen Labrador Retrievers (4-11 years old) exhibited centrilobular hepatitis with copper and hemosiderin-laden macrophages.
Associated lesions included pigmented granulomas, hepatocellular necrosis, cholestasis, and fibrosis.
Liver copper levels exceeded 2,000 parts per million dry weight in most affected dogs.

Conclusions:

Findings are consistent with primary copper-associated hepatitis in Labrador Retrievers.
Suggests a potential breed predisposition to copper accumulation and hepatitis.