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Related Experiment Video

Updated: Jun 26, 2026

Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy

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Soluble thrombomodulin protects ischemic kidneys.

Asif A Sharfuddin¹, Ruben M Sandoval, David T Berg

¹Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Journal of the American Society of Nephrology : JASN

|January 30, 2009

Summary

This summary is machine-generated.

Soluble thrombomodulin (sTM) protects against ischemic acute kidney injury (AKI) by improving microvascular function and reducing inflammation. This suggests sTM holds therapeutic potential for kidney injury.

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Area of Science:

Nephrology
Vascular Biology
Coagulation and Inflammation

Background:

Ischemic acute kidney injury (AKI) involves complex interactions between coagulation and inflammation.
Thrombomodulin plays a crucial role in anticoagulation and possesses anti-inflammatory properties.

Purpose of the Study:

To investigate the therapeutic potential of soluble thrombomodulin (sTM) in a rat model of ischemic kidney injury.
To elucidate the mechanisms underlying sTM's protective effects in hypoperfusion-induced AKI.

Main Methods:

A rat model of renal ischemia-reperfusion (I-R) injury was established by clamping the suprarenal aorta.
Soluble thrombomodulin (sTM) was administered before or after ischemia to assess its protective effects.
Intravital two-photon and multiphoton microscopy were employed to evaluate microvascular function, endothelial permeability, and leukocyte-endothelial interactions.

Main Results:

sTM pretreatment significantly attenuated renal dysfunction and acute tubular necrosis (ATN) following I-R injury.
sTM improved microvascular erythrocyte flow, reduced leukocyte adhesion, and minimized endothelial hyperpermeability.
Delayed sTM administration (2 hours post-reperfusion) also conferred protection and improved survival, independent of protein C activation.

Conclusions:

Soluble thrombomodulin demonstrates significant renoprotective effects in a model of ischemic AKI.
sTM's benefits are mediated through improvements in microvascular function and reduction of inflammatory responses.
These findings highlight the therapeutic potential of sTM for managing ischemic acute kidney injury.