A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics
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K Komiyama1, S Funayama, Y Anraku
1Kitasato Institute, Tokyo, Japan.
The Journal of Antibiotics
|August 1, 1991
Abstract:
A new antibiotic, okicenone was isolated from the culture broth of Streptomyces sp. KO-3599. The antibiotic possesses cytocidal activity against mammalian tumor cells in vitro at concentrations of 0.53-11.0 micrograms/ml whereas the antibiotic showed no antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1,000 micrograms/ml.