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Published on: April 12, 2019
Giant basal cell carcinoma masquerading as an osteogenic sarcoma
Paul Cherian1, Prasad Kumarasinghe
1Department of Dermatology, Royal Perth Hospital, Western Australia, Australia. pcherian1@hotmail.com
The Australasian Journal of Dermatology
|January 31, 2009
Summary
This study reports a rare case of invasive basal cell carcinoma developing over a clavicular fracture. It highlights the potential role of peri-fracture cytokines in basal cell neoplasm behavior.
Area of Science:
- Dermatology
- Oncology
- Orthopedics
Background:
- Basal cell carcinoma (BCC) is the most common skin cancer, rarely presenting as a rapidly growing, invasive mass.
- Fracture sites are rich in cytokines, which may influence local tissue behavior.
Observation:
- An 88-year-old male presented with an 11-month history of a large (8x6 cm), painful, ulcerated mass over a clavicular fracture.
- The mass was fixed to deeper structures, with imaging revealing extensive invasion into muscle, bone, and potentially lung parenchyma.
Findings:
- Biopsies confirmed invasive basal cell carcinoma.
- The patient's advanced age and complications from diagnostic procedures led to palliative radiotherapy for the cutaneous lesion.
Implications:
- This case underscores the importance of considering unusual presentations of BCC, particularly in areas of chronic inflammation or injury.
- Further research into the role of peri-fracture cytokines in the tumorigenesis and behavior of basal cell neoplasms is warranted.
