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Cranial mediastinal carcinomas in nine dogs
J M Liptak1, D A Kamstock, W S Dernell
1Animal Cancer Center College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. jliptak@uoguelph.ca
Veterinary and Comparative Oncology
|January 31, 2009
Summary
Cranial mediastinal carcinomas in dogs can be surgically treated, with a median survival of 243 days. Despite invasive potential, local invasion and metastasis did not negatively impact survival in this study.
Area of Science:
- Veterinary Oncology
- Comparative Pathology
Background:
- Cranial mediastinal carcinomas are rare in dogs.
- Histological subtypes include ectopic thyroid and neuroendocrine carcinomas.
Purpose of the Study:
- To characterize cranial mediastinal carcinomas in dogs.
- To evaluate clinical presentation, treatment outcomes, and survival.
Main Methods:
- Histological and immunohistochemical analysis of nine canine cranial mediastinal carcinomas.
- Evaluation of clinical signs, surgical resection, and adjunctive therapies.
- Survival analysis.
Main Results:
- Four ectopic follicular cell thyroid carcinomas, one ectopic medullary cell thyroid carcinoma, two neuroendocrine carcinomas, and two anaplastic carcinomas were identified.
- Surgical resection was attempted in eight dogs, with complete resection in six.
- Median survival time was 243 days; local invasion, pleural effusion, and metastasis did not significantly impact survival.
Conclusions:
- Cranial mediastinal carcinomas in dogs encompass diverse histological types.
- Surgical management can be successful, and survival is not negatively affected by local invasion or metastasis in this cohort.
