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Updated: Jun 26, 2026
09:41
A Method For Production of Recombinant mCD1d Protein in Insect Cells.
Published on: December 10, 2007
Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells
Michael I Zimmer1, Hanh P Nguyen, Bin Wang
1Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
Summary
Polymorphisms in CD1d molecules influence how lipid antigens are presented to T cells. These variations impact natural killer T (NKT) cell development and responses, highlighting their role in immune system function.
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- CD1 proteins are antigen-presenting molecules crucial for lipid antigen presentation to T cells.
- Unlike highly polymorphic MHC molecules, CD1 proteins show limited sequence diversity.
Purpose of the Study:
- To identify and characterize CD1d alleles in wild-derived mouse strains.
- To investigate the impact of CD1d polymorphisms on T cell responses and development.
Main Methods:
- Identification and characterization of CD1d alleles.
- Analysis of ligand presentation to CD1d-restricted T cells (type I and type II NKT cells).
- Use of congenic mice to study thymic selection and allogeneic T cell responses.
Main Results:
- CD1d polymorphisms were identified in wild-derived mouse strains.
- These polymorphisms affect the presentation of both endogenous and exogenous ligands.
- CD1d variations influence the thymic selection of type I NKT cells and induce allogeneic T cell responses.
Conclusions:
- Polymorphisms in CD1d molecules play a significant role in shaping the repertoire and function of CD1d-restricted T cells.
- Understanding CD1d diversity is key to comprehending T cell-mediated immunity to lipid antigens.
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