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Updated: Jun 26, 2026

A Method For Production of Recombinant mCD1d Protein in Insect Cells.
Published on: December 10, 2007
Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells
Michael I Zimmer1, Hanh P Nguyen, Bin Wang
1Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
Abstract:
CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity. Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains. We demonstrate that polymorphisms in CD1d affect the presentation of endogenous and exogenous ligands to CD1d-restricted T cells, including type I (Valpha14i) and type II (non-Valpha14i) natural killer T (NKT) cells. Using congenic mice, we found CD1d polymorphisms affect the thymic selection of type I NKT cells and induce allogeneic T cell responses. Collectively, results from these studies demonstrate a role for polymorphisms in influencing the development and function of CD1d-restricted T cells.
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