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Related Experiment Video

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Cohesive versus flexible evolution of functional modules in eukaryotes.

Like Fokkens¹, Berend Snel

¹Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands. l.fokkens@uu.nl

Plos Computational Biology

|January 31, 2009

Summary

This summary is machine-generated.

Most eukaryotic functional modules evolve flexibly, not cohesively. This study quantifies evolutionary cohesiveness in protein complexes and pathways, finding significant flexibility even after corrections.

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Area of Science:

Evolutionary biology
Systems biology
Bioinformatics

Background:

Phylogenetic profiles can predict functionally related proteins.
However, many functional modules in prokaryotes do not evolve cohesively.

Purpose of the Study:

Quantify the evolutionary cohesiveness of functional modules in eukaryotes.
Investigate biological and methodological factors influencing cohesiveness estimates.

Main Methods:

Collected protein complex and pathway datasets from Saccharomyces cerevisiae.
Defined orthologous groups across 34 eukaryotic genomes.
Measured cohesive evolution of orthologous group sets constituting known complexes/pathways.

Main Results:

Most functional modules exhibit flexible, rather than cohesive, evolution.
Only 46% of pathways and complexes showed more cohesive evolution than random modules, even after corrections.
Biochemical pathways generally evolve more cohesively than protein complexes.

Conclusions:

Eukaryotic functional modules display significant evolutionary flexibility.
Module definition and orthologous group quality impact cohesiveness estimates.
The nature of the module (pathway vs. complex) influences its evolutionary pattern.