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Systemic correlates of angiographic coronary artery disease

José Pedro L Nunes1, João Carlos Silva

  • 1Faculdade de Medicina da Universidade do Porto, Porto, Portugal. jplnunes@med.up.pt

Plos One
|January 31, 2009
PubMed

Insights

Fasting plasma glucose levels show a significant correlation with the severity of coronary artery disease (CAD). This observational study highlights glucose as a key systemic parameter linked to atherosclerosis progression in patients diagnosed via coronary angiography.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Biochemistry

Background:

  • Coronary angiography is a primary diagnostic tool for evaluating coronary artery anatomy.
  • Understanding systemic factors associated with coronary artery disease (CAD) burden is crucial for patient management.

Purpose of the Study:

  • To investigate correlations between the extent of coronary artery disease (CAD) and various systemic parameters.
  • To identify key predictors of CAD severity using statistical analysis.

Main Methods:

  • An observational study involving 116 patients with angiographically diagnosed coronary heart disease.
  • Correlation and linear regression analyses were performed using coronary artery disease burden (CADB) as the dependent variable.
  • Independent variables included age, sex, plasma calcium, phosphorus, magnesium, glucose, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, estimated glomerular filtration rate, and body mass index.

Main Results:

  • Significant correlations were found between CADB and age (r=0.19, p=0.04), uric acid (r=0.18, p=0.048), and fasting plasma glucose (r=0.33, p<0.001).
  • Linear regression analysis indicated that plasma glucose (p=0.018) and sex (p=0.008) were significant predictors of CADB.
  • The overall model for linear regression was globally significant (p=0.002).

Conclusions:

  • Plasma glucose levels demonstrated a significant correlation with coronary artery atherosclerosis lesions.
  • Fasting plasma glucose emerges as a key systemic parameter associated with the burden of coronary artery disease.

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