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Tolerance in Drosophila.

Nigel S Atkinson1

  • 1Section of Neurobiology and The Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712-0248, USA. NigelA@mail.utexas.edu

Journal of Neurogenetics
|January 31, 2009
PubMed
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Genes for ethanol tolerance in fruit flies (Drosophila melanogaster) are being identified. These genes may also play a role in ethanol addiction and have relevance in mammals, aiding addiction research.

Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Ethanol tolerance, a form of inducible resistance, shares genetic underpinnings with ethanol addiction.
  • Behavioral tolerance is easily studied in model organisms, unlike addiction.
  • Powerful genetic systems are ideal for analyzing the molecular basis of tolerance.

Purpose of the Study:

  • To discuss genes identified as crucial for ethanol tolerance development in Drosophila melanogaster.
  • To highlight the overlap between genes involved in ethanol tolerance and addiction.
  • To demonstrate the predictive value of Drosophila gene discovery for mammalian tolerance pathways.

Main Methods:

  • Utilizing Drosophila melanogaster as a model system for genetic analysis.
  • Identifying genes that influence the acquisition of ethanol tolerance.

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  • Comparing identified Drosophila genes with those known to be involved in mammalian tolerance.

    • Main Results:

    • Several genes critical for the development of ethanol tolerance in Drosophila have been identified.
    • A subset of these genes also plays a role in mammalian ethanol tolerance.
    • This suggests conserved molecular pathways underlying ethanol tolerance across species.

    Conclusions:

    • Drosophila melanogaster is a valuable model for dissecting the genetic architecture of ethanol tolerance.
    • Gene discovery in Drosophila offers insights into the molecular mechanisms of ethanol addiction.
    • Findings in Drosophila have direct translational relevance for understanding and treating alcohol use disorders in mammals.