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Updated: Jun 26, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
[Epidemiology of cutaneous vascular neoplasms and malformations in childhood]
1Universitätsklinik für Dermatologie, Medizinische Universität Innsbruck. alexis.sidoroff@i-med.ac.at
Insights
Vascular lesions are common in children, with most being harmless. About 1% of children may need treatment for conditions like strawberry angiomas and port-wine stains.
Area of Science:
- Pediatric dermatology
- Epidemiology of vascular lesions
- Congenital vascular anomalies
Context:
- Benign cutaneous vascular neoplasms and malformations are common in infants and children.
- Understanding their incidence and prevalence is crucial for appropriate management.
- Previous epidemiological data has been limited.
Purpose:
- To compile representative data on the incidence and prevalence of benign cutaneous vascular neoplasms and malformations in childhood.
- To evaluate data from an epidemiological survey in 6-year-old children.
Summary:
- Capillary malformations (salmon patches) occur in 20-30% of newborns, while persistent port-wine stains affect about 1%.
- Strawberry angiomas are seen in 3% of full-term newborns and up to 12.5% of preterm infants.
- Complex vascular malformations and severe vascular tumors are rare.
Impact:
- Vascular lesions are frequent in childhood, often transient and benign.
- Approximately 1% of children may require treatment for conditions like strawberry angiomas and port-wine stains.
- Severe, life-threatening vascular tumors and malformations requiring complex treatment are extremely rare.
Purpose:
A representative compilation of data on the incidence and prevalence of benign cutaneous vascular neoplasms and malformations in childhood has been made.
Patients, Materials And Methods:
A review of the literature has been made and basic data from an own epidemiological survey in the province of Tyrol (Austria) in 6-year-old children are evaluated.
Results:
For capillary malformations with spontaneous regression (salmon patches), the reported numbers usually vary between 20 and 30% of the newborns, while true, persisting capillary malformations (port-wine stains) can be found in about 1%. Strawberry angiomas are found in about 3% of mature newborns but in up to 12.5% of preterm children. Complex vascular malformations or severe cases of vascular tumours are very rare.
Conclusion:
All in all, vascular lesions are very common findings in childhood, but in most cases harmless and transient in nature. The number of lesions that may require adequate but usually uncomplicated treatment amounts to about one percent of children (strawberry angiomas and port-wine stains). Complex and/or life-threatening severe vascular tumours and malformations that represent a considerable therapeutic challenge are extremely rare events.
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