Related Experiment Video
Updated: Jun 26, 2026
08:28
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
Published on: May 21, 2020
Characteristics of the parallel-plate flow chamber for mechanical stimulation of bone cells under microgravity
R G Bacabac1, Th H Smit, R M Heethaar
1ACTA-Vrije Universiteit, Dept Oral Cell Biology, Van der Boechorststraat, Amsterdam, The Netherlands. rg.bacabac.ocb.acta@med.vu.nl
Journal of Gravitational Physiology : a Journal of the International Society for Gravitational Physiology
|February 3, 2009
Abstract:
We show the use of a dimensionless parameter alpha h, in properly downscaling a parallel-plate flow chamber system for flow stimulation of bone cells under microgravity. The proper experimental regime for exposing cells to predictable levels of dynamic fluid shear stress requires: 1) alpha h < 2, based on the consequent quasi-parabolic form of the velocity profile in this regime, and 2) fo m
