Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Esophageal Achalasia

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assessing gait parameters with accelerometer-based methods to identify older adults at risk of falls: a systematic review.

European geriatric medicine·2021

Same author

[Benefits and limitations of geriatric dysphagia screening tools].

Revue medicale de Liege·2021

Same author

Clinical Impact of Nutritional Status and Energy Balance in Elderly Hospitalized Patients.

The journal of nutrition, health & aging·2020

Same author

[Critical assessment of long-term proton pump inhibitor use in the elderly].

Revue medicale de Liege·2020

Same author

[Frailty in nursing home : contribution of the SENIOR study].

Revue medicale de Liege·2019

Same author

Impact of frailty status on the cost of drugs and dietary supplements prescribed to nursing home residents: the SENIOR cohort.

Aging clinical and experimental research·2019

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

[Swallowing disorders in the elderly: an underestimated problem].

S Allepaerts¹, S Delcourt, J Petermans

¹Service de Gériatrie, CHU Sart Tilman, Liège. sallepaerts@chu.ulg.ac.be

Revue Medicale De Liege

|February 3, 2009

Summary

Swallowing disorders, common in older adults, pose serious health risks like pneumonia and malnutrition. Diagnosis is challenging, requiring a multidisciplinary approach rather than isolated medical or surgical interventions.

More Related Videos

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Published on: March 1, 2015

Related Experiment Videos

Last Updated: Jun 26, 2026

Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Published on: March 1, 2015

Area of Science:

Gerontology
Gastroenterology
Neurology

Context:

Swallowing disorders (dysphagia) are prevalent in the elderly population.
Often associated with underlying organic pathologies.
Pose significant risks including aspiration pneumonia, malnutrition, and dehydration.

Purpose:

To highlight the diagnostic challenges of swallowing disorders in the elderly.
To emphasize the limitations of purely medical or surgical treatments.
To underscore the necessity of a comprehensive, multidisciplinary management strategy.

Summary:

Dysphagia in the elderly frequently accompanies organic diseases, presenting life-threatening complications.
Diagnosis involves a combination of patient history, clinical assessment, and specialized investigations.
Effective management necessitates an integrated, multidisciplinary approach, as specific medical or surgical options are limited.

Impact:

Improves understanding of the complexities surrounding geriatric dysphagia.
Promotes a shift towards holistic patient care models.
Aims to reduce morbidity and mortality associated with swallowing difficulties in older adults.