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Published on: November 18, 2016
In vitro cyto-biocompatibility and cell detachment of temperature-sensitive dextran hydrogel
Fei Xiao1, Li Chen, Rui-Feng Xing
1Tianjin Key Laboratory of Fiber Modification and Functional Fiber, School of Materials Science and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300160, China.
Abstract:
A series of poly(NIPAAm-co-GMA-Dex) hydrogels were synthesized from glycidyl methacrylate-derivatized dextran (GMA-Dex) and N-isopropylacrylamide (NIPAAm) in aqueous solution. The swelling properties, cell culture and detachment behaviors of these hydrogels were investigated. It has found that poly(NIPAAm-co-GMA-Dex) hydrogels are not only sensitive to temperature in deionized water and Dulbecco's modified eagle medium (DMEM) (10% FBS), but also exhibit good biocompatibility. In addition, L929 cells were found to detach from the hydrogel surface naturally without affecting the function of L929 by controlling environmental temperature.
