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DNA sequencing, today and tomorrow.

W Gilbert1

  • 1Department of Cellular and Developmental Biology, Harvard University, Cambridge.

Hospital Practice (Office Ed.)
|October 15, 1991
PubMed
Summary

The complete human genome sequence, expected around 2000, will enable efficient identification of genes linked to complex diseases like cancer. This will shift focus to fundamental questions in human biology.

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Area of Science:

  • Genomics
  • Human Biology
  • Disease Genetics

Background:

  • The early stages of the Human Genome Project aimed to map and sequence the entire human genome.
  • Understanding the genetic basis of multifactorial diseases remained a significant challenge.

Purpose of the Study:

  • To outline the potential impact of a completed human genome sequence on biomedical research.
  • To highlight the future research directions enabled by comprehensive genomic data.

Main Methods:

  • Anticipation of the completion of the human genome sequencing project.
  • Forecasting the application of genomic data in disease gene discovery.

Main Results:

  • The completed genome sequence will facilitate more efficient searching for genes implicated in multifactorial diseases, such as various cancers.
  • Identification of the full complement of human genes will be achieved.

Conclusions:

  • The availability of the complete genome sequence by 2000 is predicted to revolutionize the study of complex diseases.
  • Fundamental questions regarding common human biology will become central research topics in the 21st century.

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