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Related Concept Videos

Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
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Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
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Long-term suppressive therapy for herpes simplex - an audit.

O A Deko1, A Pakozdi, D T P Evans

  • 1Department of Genito-Urinary Medicine, Southend University Hospital NHS Foundation Trust, Prittlewell Chase, WestCliff-on-Sea, Essex SS0 0RY, UK.

International Journal of STD & AIDS
|February 3, 2009
PubMed
Summary

Long-term suppressive therapy for recurrent herpes simplex (HSV) was analyzed. Most patients had chronic infections and frequent outbreaks, with few experiencing treatment interruptions, showing mixed adherence to guidelines.

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Area of Science:

  • Medical Research
  • Infectious Diseases
  • Virology

Background:

  • Recurrent herpes simplex virus (HSV) infections pose a significant challenge.
  • Long-term suppressive therapy is a common management strategy.
  • Assessing adherence to treatment guidelines is crucial for effective patient care.

Purpose of the Study:

  • To evaluate the effectiveness and adherence to guidelines of long-term suppressive therapy for recurrent HSV infections.
  • To analyze patient data from a university hospital between 2000 and 2007.

Main Methods:

  • Retrospective analysis of patient records.
  • Documentation and graphical representation of findings.
  • Comparison of patient outcomes with British Association for Sexual Health and HIV guidelines.

Main Results:

  • 82% of patients had HSV for at least 12 months prior to therapy.
  • 78.2% experienced at least six recurrences annually before treatment.
  • Only 5.8% had treatment interruptions within 12 months; 15.9% had fewer than six outbreaks at baseline.

Conclusions:

  • Patient profiles indicate long-standing, frequent HSV recurrences before suppressive therapy.
  • Treatment interruption rates suggest good patient compliance, but baseline recurrence rates were often higher than guideline recommendations.
  • The study highlights areas for improved patient selection and management in HSV suppressive therapy.