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Chronic kidney disease and clinical outcome in patients with acute stroke

Gilad Yahalom1, Roseline Schwartz, Yvonne Schwammenthal

  • 1Department of Neurology, Stroke Center, Tel Hashomer, Israel.

Stroke
|February 3, 2009
PubMed

Insights

Chronic kidney disease (CKD) significantly increases mortality risk after acute stroke. Early identification of CKD is crucial for predicting poor stroke outcomes and improving patient care.

Area of Science:

  • Nephrology
  • Neurology
  • Cardiology

Background:

  • Chronic kidney disease (CKD) is an emerging risk factor for cardiovascular events, including stroke.
  • Understanding the impact of CKD on stroke outcomes is critical for patient management.

Purpose of the Study:

  • To investigate the association between estimated glomerular filtration rate (GFR) and stroke outcomes.
  • To determine if CKD and its severity influence outcomes in patients with acute stroke.

Main Methods:

  • A cohort of 821 acute stroke patients (ischemic or hemorrhagic) was analyzed.
  • Glomerular filtration rate (GFR) was estimated using the Modification of Diet in Renal Disease (MDRD) and Mayo Clinic quadratic equations.
  • Chronic kidney disease (CKD) was defined as an estimated GFR

Main Results:

  • Prevalence of CKD varied by estimation method: 36% (MDRD) vs. 18% (Mayo Clinic).
  • Higher CKD severity correlated with increased 1-year mortality risk, with adjusted odds ratios ranging from 2.3 to 3.3.
  • Poor functional outcomes (Barthel Index

Conclusions:

  • Chronic kidney disease (CKD) is a significant independent predictor of mortality and poor outcomes following acute stroke.
  • The estimated prevalence of CKD and GFR thresholds for adverse outcomes are dependent on the GFR estimation equation used.
Abstract

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