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Tourette syndrome and comorbid pervasive developmental disorders.
Larry Burd1, Qing Li, Jacob Kerbeshian
1Department of Pediatrics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202-9037, USA. laburd@medicine.nodak.edu
Journal of Child Neurology
|February 3, 2009
Summary
Tourette syndrome frequently co-occurs with pervasive developmental disorders, affecting 1 in 22 individuals. Patients with both conditions often have additional comorbidities, highlighting a complex relationship.
Area of Science:
- Neurodevelopmental Disorders
- Genetics
- Clinical Neurology
Background:
- Tourette syndrome is a neurological disorder characterized by tics.
- Pervasive developmental disorders encompass a range of developmental impairments.
- Understanding the comorbidity between these conditions is crucial for patient care.
Purpose of the Study:
- To determine the prevalence of pervasive developmental disorders in individuals with Tourette syndrome.
- To identify factors associated with the co-occurrence of Tourette syndrome and pervasive developmental disorders.
Main Methods:
- Utilized data from 7288 participants in the Tourette Syndrome International Database Consortium Registry.
- Conducted logistic modeling to identify significant predictors of comorbid conditions.
Main Results:
- Found that 4.6% of participants with Tourette syndrome also had a pervasive developmental disorder.
- Individuals with both conditions had significantly higher rates of other comorbidities (98.8%) compared to those with Tourette syndrome alone (13.2%).
- Male gender, absence of a family history of tics, and a higher number of comorbidities predicted the co-occurrence of Tourette syndrome and pervasive developmental disorders.
Conclusions:
- The rate of comorbid Tourette syndrome and pervasive developmental disorders is significantly elevated (13-fold).
- Identifying distinct patient subgroups can enhance understanding of susceptibility, severity, and outcomes.
- Further research into these comorbid conditions is warranted for improved therapeutic strategies.
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