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Updated: Jun 26, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
An unusual thrombotic complication during percutaneous closure of atrial septal defect
Sasidharan Bijulal1, Sivasubramanian Sivasankaran, V K Ajitkumar
1Department of Cardiology, SCTIMST, Trivandrum, Kerala, India 695 011. bijulalsasidharan@gmail.com
Insights
Intracardiac thrombus formation occurred during an attempted atrial septal defect closure using a device. Prolonged procedure time and multiple device deployments likely caused this complication, necessitating urgent surgical intervention.
Area of Science:
- Cardiology
- Medical Devices
- Surgical Procedures
Background:
- Atrial septal defects (ASDs) are commonly closed percutaneously using device closure.
- Device closure of ASDs requires precise deployment and can be challenging in certain anatomies.
Observation:
- A rare case of intracardiac thrombus formation was observed at the superior vena cava-right atrium junction.
- This complication arose during an attempted percutaneous closure of an ASD using a device similar to the Amplatzer septal occluder.
Findings:
- The intracardiac thrombus was likely associated with multiple device deployment attempts and prolonged procedural duration.
- The patient required urgent surgical closure of the ASD due to the thrombus complication.
Implications:
- This case highlights a potential risk of intracardiac thrombus formation during complex ASD device closures.
- Careful procedural planning and execution are crucial to minimize procedural time and device manipulation, thereby reducing thrombosis risk.
- Further research may be warranted to identify predictive factors and preventative strategies for thrombosis during ASD device closure.
Abstract:
A case is described where intracardiac thrombus was observed at the junction of the superior vena cava and the right atrium during attempted closure of an atrial septal defect (ASD) using a device similar in design to the Amplatzer septal occluder (Heart R atrial septal occluder). Thrombosis was likely related to the multiple attempts required when deploying the device and the attendant prolonged procedural time. The patient underwent subsequent urgent surgical closure of the ASD.
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