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A sensitive fluorescence assay for the simultaneous and separate determination of arylsulphatases A and B

H Christomanou, K Sandhoff

Clinica Chimica Acta; International Journal of Clinical Chemistry

|September 15, 1977

Abstract:

A sensitive fluorometric assay utilizing 4-methylumbelliferyl sulphate has been developed for the simultaneous determination of arylsulphatases A and B from leucocytes, based on the differential effect of silver ions on the two enzymes. The procedure allows discrimination between normal cases and those with metachromatic leucodystrophy.

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