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Related Experiment Video

Updated: Jun 26, 2026

Implantation of the Syncardia Total Artificial Heart
16:11

Implantation of the Syncardia Total Artificial Heart

Published on: July 18, 2014

A nonpulsatile total artificial heart with 1/R control.

Yusuke Abe1, Itsuro Saito, Takashi Isoyama

  • 1Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. abe@bme.rcast.u-tokyo.ac.jp

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
|February 3, 2009
PubMed
Summary

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Nonpulsatile total artificial hearts (TAH) with 1/R control are feasible but cause hemolysis due to atrial suction. Introducing some pulsatility is crucial for TAH viability.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Devices

Background:

  • Continuous flow pumps in total artificial hearts (TAHs) offer size reduction but raise questions about the necessity of pulsatility.
  • The efficacy of physiological control methods, like 1/R control, in nonpulsatile TAHs remains unclear.

Purpose of the Study:

  • To investigate the feasibility of a nonpulsatile total artificial heart (TAH) using 1/R control.
  • To assess the physiological impact and long-term viability of nonpulsatile TAH operation in an experimental animal model.

Main Methods:

  • Modified undulation pump total artificial hearts (UPTAHs) without artificial valves were used to enable both pulsatile and nonpulsatile flow.
  • UPTAHs were implanted into 18 goats, with survival and physiological parameters monitored during nonpulsatile operation.

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Last Updated: Jun 26, 2026

Implantation of the Syncardia Total Artificial Heart
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Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
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Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

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  • 1/R control was implemented and tested in both pulsatile and nonpulsatile modes.

    • Main Results:

    • Four goats survived for over 1 month, with one goat tolerating 3 weeks of continuous nonpulsatile TAH operation.
    • 1/R control was demonstrated to be effective in both pulsatile and nonpulsatile TAH configurations.
    • Nonpulsatile mode did not significantly alter the overall condition or organ function of the goats, with similar hemodynamic responses to pulsatile mode.
    • Significant atrial suction effects and resultant hemolysis were observed during nonpulsatile operation, alongside pressure fluctuations potentially linked to respiration.

    Conclusions:

    • While 1/R control is viable for nonpulsatile TAHs, the associated atrial suction and hemolysis pose significant risks.
    • Nonpulsatile TAHs require the incorporation of some pulsatility to mitigate adverse effects and ensure adequate inflow.
    • Further research is needed to optimize nonpulsatile TAH designs to balance device efficiency with physiological compatibility.