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Related Experiment Videos

Experimental copper and heliotrope intoxication in sheep: morphological changes.

J M Howell1, H S Deol, P R Dorling

  • 1School of Veterinary Studies, Murdoch University, Western Australia.

Journal of Comparative Pathology
|July 1, 1991
PubMed
Summary
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Heliotrope and copper toxicity in sheep is enhanced when fed together. Concurrent or sequential feeding of these substances caused severe liver damage and copper accumulation, indicating a synergistic toxic effect.

Area of Science:

  • Veterinary Toxicology
  • Animal Science
  • Trace Element Metabolism

Background:

  • Heliotrope (Senecio jacobaea) contains pyrrolizidine alkaloids, known hepatotoxins.
  • Copper is an essential trace element but can be toxic at high concentrations.
  • The combined toxic effects of heliotrope and copper in sheep are not fully understood.

Purpose of the Study:

  • To investigate the synergistic toxicity of copper and heliotrope in young Merino wethers.
  • To determine the effects of concurrent and sequential administration of these substances on toxicity development.
  • To analyze the concentration of trace elements, particularly copper, in the liver and kidney.

Main Methods:

  • Young Merino wethers were divided into groups receiving heliotrope alone, copper alone, or a combination of both.

Related Experiment Videos

  • Heliotrope and copper were administered concurrently or sequentially in different experimental setups.
  • Clinical signs, post-mortem lesions, and trace element concentrations (copper) in liver and kidney tissues were assessed.

    • Main Results:

    • Heliotrope alone caused liver damage without significant copper accumulation or clinical illness.
    • Copper alone induced clinical signs and lesions of haemolysis in some sheep.
    • Concurrent or sequential feeding of heliotrope and copper markedly enhanced toxicity, leading to severe liver damage, jaundice, haemolysis, and excessive copper accumulation in the liver.

    Conclusions:

    • Heliotrope potentiates the toxicity of copper, and vice versa, suggesting a synergistic interaction.
    • The combination of heliotrope and copper leads to significant hepatotoxicity and excessive copper accumulation.
    • This study highlights the increased risk associated with co-exposure to pyrrolizidine alkaloids and copper in susceptible animals.