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Updated: Jun 26, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Erythropoietin levels in cardiac resynchronization therapy responders
Abstract:
Cardiac resynchronization therapy (CRT) is an effective treatment strategy in patients with severe left ventricular dysfunction and those with evidence of electro-mechanical dyssynchrony. A prospective observational study was conducted in patients with severe symptomatic heart failure undergoing CRT implantation. Thirty patients were classified as either responders (9 patients), or non-responders (21 patients). The association between functional status, quality of life scores and CRT responder status with erythropoietin (EPO) levels was determined. The mean EPO levels among responders were 28.8±3.6 and 11.4±1.7 mIU/ml among non-responders. Elevated EPO levels in the absence of anemia and renal insufficiency effectively correlate with functional impairment and severe symptoms, which impair quality of life in patients undergoing CRT.
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