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Updated: Jun 26, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
Published on: April 11, 2025
PI 3-kinase and cancer: changing accents
Peter K Vogt1, Marco Gymnopoulos, Jonathan R Hart
1Department of Molecular and Experimental Medicine, Division of Oncovirology, The Scripps Research Institute, La Jolla, CA 92037, USA. pkvogt@scripps.edu
Abstract:
Research on PI 3-kinase (PI3K) is undergoing significant shifts in emphasis. Questions that have been dormant for some time are coming to the forefront, such as the relationship of PTEN to PI3K and the role of AKT in PI3K-driven oncogenesis. Two non-alpha isoforms of Class I PI3K are now established as important determinants in cancer: p110beta and p110delta. The oncogenic activities of p110beta include a non-catalytic function, a finding that will have immediate consequences for drug development.
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