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Related Experiment Video

Updated: Jun 26, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Autophagy in Candida albicans.

Glen E Palmer¹

¹Department of Oral and Craniofacial Biology, LSUHSC School of Dentistry, New Orleans, Louisiana, USA.

Methods in Enzymology

|February 3, 2009

Summary

This study explores autophagy in Candida albicans, an opportunistic pathogen. Methods are presented to detect autophagy, aiding research into fungal adaptation and potential therapeutic strategies.

Area of Science:

Microbiology
Mycology
Cell Biology

Background:

Candida albicans is a human commensal that can become pathogenic when host defenses weaken.
This fungus can cause mucosal infections and serious disseminated disease.
C. albicans exhibits remarkable adaptability, transitioning from commensal to pathogen.

Purpose of the Study:

To investigate the role of autophagy in Candida albicans colonization, persistence, and pathogenicity.
To explore the therapeutic potential of targeting fungal autophagy.
To describe methods for detecting autophagy in C. albicans.

Main Methods:

Adaptation of established methods to detect autophagy.
Application of these methods to the opportunistic pathogen C. albicans.

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Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

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Live-cell Video Microscopy of Fungal Pathogen Phagocytosis

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Use of In Vivo Imaging to Screen for Morphogenesis Phenotypes in Candida albicans Mutant Strains During Active Infection in a Mammalian Host

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Main Results:

The study presents adapted methodologies for autophagy detection in C. albicans.
These methods facilitate further investigation into fungal adaptive responses.

Conclusions:

Autophagy's role in C. albicans pathogenesis remains underexplored.
Developing methods to detect autophagy is crucial for understanding and potentially treating C. albicans infections.