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Updated: Jun 26, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Estrogen receptor beta gene +1730 G/A polymorphism in women with polycystic ovary syndrome
Jin Ju Kim1, Young Min Choi, Seon Ha Choung
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea.
Objective:
To investigate whether the +1730 G/A polymorphism in the estrogen receptor (ER)-beta gene is associated with susceptibility to polycystic ovary syndrome (PCOS).
Design:
Case-control study.
Setting:
University Department of Obstetrics and Gynecology.
Patient(S):
Women with (n = 138) or without (n = 290) PCOS.
Intervention(S):
Genotyping was performed by polymerase chain reaction-restriction fragment-length polymorphism analysis.
Main Outcome Measure(S):
Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene.
Result(S):
There was a significant difference in the genotype distribution between the patients with PCOS and controls (non-GG rates were 22.1% for patients with PCOS and 36.6% for controls). There was also a significant difference in the G and A allele frequencies between these two groups (11.7% in patients vs. 19.1% in controls with A allele). But in patients with PCOS there were no significant differences in the serum levels of hormones, biochemical variables, or ovarian morphology between GG and non-GG genotypes.
Conclusion(S):
The ER-beta gene +1730 G/A polymorphism may be associated with pathophysiologic aberrancies involved in PCOS.
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