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Updated: Jun 26, 2026

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease
Published on: August 26, 2017
[Remodelling of peripheral vessels in cardiovascular diseases: pathogenesis and treatment with telmisartan]
Abstract:
The authors present remodelling mechanisms of distal peripheral vessels in vibration disease, caused by endothelium functions disorder (lower NO, increased endothelin-1 and Villebrandt factor), stressed oxidative metabolism in neutrophils, intensified lipid peroxidation, depressed antioxidant defence, activated anti-inflammatory cytokines (TNF-alpha, IL-1beta) and hyperhomocysteinemia. Degree of the changes increases with combination of vibration disease and arterial hypertension. The data justify application of Telmisartan improving functional state of endothelium.
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