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Related Concept Videos

DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA as a Genetic Template02:05

DNA as a Genetic Template

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Cellulose and Pectic Polysaccharides01:15

Cellulose and Pectic Polysaccharides

Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth.  Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the parenchyma cells of...
DNA Agarose Gel Electrophoresis02:35

DNA Agarose Gel Electrophoresis

Agarose gel electrophoresis is a laboratory technique commonly used to separate DNA fragments by size. However, it can also be used to isolate and purify DNA fragments using a gel extraction protocol.
Gel extraction follows five major steps: running gel electrophoresis to separate fragments, isolating the individual bands, extracting DNA from those bands, and removing the dye and salts from the extracted mixture to obtain pure DNA.
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Updated: Jun 26, 2026

Highly Stable, Functional Hairy Nanoparticles and Biopolymers from Wood Fibers: Towards Sustainable Nanotechnology
11:32

Highly Stable, Functional Hairy Nanoparticles and Biopolymers from Wood Fibers: Towards Sustainable Nanotechnology

Published on: July 20, 2016

Cellulose/DNA hybrid nanomaterials.

Anand P Mangalam1, John Simonsen, Albert S Benight

  • 1Department of Wood Science and Engineering, Oregon State University, Corvallis, Oregon 97331, USA.

Biomacromolecules
|February 4, 2009
PubMed
Summary
This summary is machine-generated.

Researchers grafted DNA onto cellulose nanocrystals (CNXLs) and used their molecular recognition to assemble them into larger structures. This DNA-guided assembly creates novel hybrid nanomaterials from CNXLs.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomaterials Engineering

Background:

  • Cellulose nanocrystals (CNXLs) exhibit exceptional mechanical properties and high aspect ratios, making them promising reinforcing agents.
  • Hierarchical assembly offers a pathway to create macroscale materials from nanoscale building blocks.

Purpose of the Study:

  • To utilize cellulose nanocrystals (CNXLs) in a bottom-up hierarchical assembly approach.
  • To create novel hybrid nanomaterials by functionalizing CNXLs with oligonucleotides.

Main Methods:

  • Grafting single-stranded oligonucleotides with amino modifiers onto CNXLs.
  • Utilizing the molecular recognition of complementary base pairs for self-assembly.
  • Characterizing the resulting hybrid nanomaterials using dynamic light scattering, atomic force microscopy, and UV spectroscopy.

Main Results:

  • Successful grafting of oligonucleotides onto CNXLs was achieved.
  • Duplexing of complementary oligonucleotides on separate CNXL populations led to hybrid nanomaterial formation.
  • The assembly process and resulting structures were confirmed through various analytical techniques.

Conclusions:

  • DNA-mediated self-assembly provides a viable strategy for creating hierarchical structures from cellulose nanocrystals.
  • This approach enables the development of advanced hybrid nanomaterials with tunable properties.
  • The findings open new avenues for designing and fabricating complex materials from renewable resources.