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Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
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Use of povidone-iodine during the first trimester of pregnancy: a correct practice?

I Velasco1, S Naranjo, C López-Pedrera

  • 1Servicio de Obstetricia y Ginecología, Hospital de Osuna, Sevilla, Spain. inesvelas@msn.com

BJOG : an International Journal of Obstetrics and Gynaecology
|February 4, 2009
PubMed

Povidone-iodine (PVP-I) has been widely used as an antiseptic agent during invasive procedures for prenatal diagnosis. Women have been reported of thyroid dysfunction after simple exposure to PVP-I. We studied the effect on thyroid function and urinary iodine excretion after a single topical application of PVP-I in 31 women who had a miscarriage during the first trimester of pregnancy. PVP-I is absorbed through the skin and the vaginal mucosa, resulting in a sudden increase in the urinary excretion of iodine and a short-term variation in concentrations of thyroid hormones in maternal serum. This metabolic effect could have consequences for the embryo and the fetus during crucial stages of development.

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