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BRCTing up is hard to do
1Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8023, USA. df.stern@yale.edu
Molecular Cell
|February 4, 2009
Abstract:
In this issue of Molecular Cell, Usui et al. (2009) show that Mec1-phosphorylated Rad9 SCD interacts with the BRCT domain, promoting oligomerization. This sustains the DNA damage checkpoint and is suppressed by Rad53 phosphorylation in a negative feedback circuit.
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