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Updated: Jun 26, 2026

Long-term Sensory Conflict in Freely Behaving Mice

Long-term Sensory Conflict in Freely Behaving Mice

Published on: February 20, 2019

Why we should put clothes on mice.

Irfan J Lodhi¹, Clay F Semenkovich

¹Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Cell Metabolism

|February 4, 2009

Summary

This summary is machine-generated.

Mice lacking mitochondrial uncoupling protein 1 (UCP1) are cold sensitive but not obese. However, maintaining these UCP1-deficient mice at thermoneutrality reveals a surprising obesity phenotype.

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Area of Science:

Biochemistry
Metabolism
Physiology

Background:

Mitochondrial uncoupling protein 1 (UCP1) regulates adaptive thermogenesis and energy expenditure.
Mice lacking UCP1 exhibit cold sensitivity but not obesity at room temperature.

Purpose of the Study:

To investigate the role of UCP1 in thermoregulation and energy balance.
To determine if an obesogenic phenotype can be unmasked in UCP1-deficient mice under specific environmental conditions.

Main Methods:

Utilizing UCP1-deficient mouse models.
Maintaining mice at thermoneutral conditions.
Assessing metabolic parameters and body composition.

Main Results:

Mice lacking UCP1 displayed cold sensitivity at room temperature.
Surprisingly, these mice were not obese at room temperature.
Maintaining UCP1-deficient mice at thermoneutrality revealed an obesogenic phenotype.

Conclusions:

UCP1 plays a critical role in preventing obesity, particularly under thermoneutral conditions.
Environmental temperature significantly influences the metabolic consequences of UCP1 deficiency.
Further research into UCP1's function in energy expenditure and obesity is warranted.